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Summary: INVARIANT 3D SPHARM FEATURES FOR CHARACTERIZING FMRI ACTIVATIONS IN
ROIS WHILE MINIMIZING EFFECTS OF INTERSUBJECT ANATOMICAL VARIABILITY
Ashish Uthama1
, Rafeef Abugharbieh1
, Samantha J. Palmer2
, Anthony Traboulsee2
and Martin J.
McKeown2
1
Biomedical Signal and Image Computing Laboratory, Department of Electrical and Computer
Engineering, 2
Department of Neurology, University of British Columbia, Vancouver V6T 1Z4, Canada
ABSTRACT
Spatial patterns of activation statistics within anatomically-defined
regions of interest (ROIs) in functional magnetic resonance
imaging (fMRI) data were recently shown to be sensitive markers
of brain activation changes. Most current methods that analyze
fMRI activation statistics largely ignore this. The accuracy and
validity of the prevalent approach of spatial normalization of
functional data is also being debated. In this paper we present a
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