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[Autophagy 5:6, 1-3; 16 August 2009]; 2009 Landes Bioscience 1 Autophagy 2009; Vol. 5 Issue 6

Summary: [Autophagy 5:6, 1-3; 16 August 2009]; 2009 Landes Bioscience
1 Autophagy 2009; Vol. 5 Issue 6
Rapamycin is an antibiotic that stimulates autophagy in a wide
variety of eukaryotes, including the budding yeast Saccharomyces
cerevisiae. Low concentrations of rapamycin extend yeast chrono-
logical life span (CLS). We have recently shown that autophagy
is required for chronological longevity in yeast, which is attribut-
able in part to a role for autophagy in amino acid homeostasis.
We report herein that low concentrations of rapamycin stimulate
macroautophagy during chronological aging and extend CLS.
The nutrient-sensing target of rapamycin (TOR) pathway is
implicated in the aging process in many organisms.1-3 In yeast, the
TOR signaling pathway has been implicated in both replicative
and chronological aging as well as in life-span extension by calorie
restriction.3-6 In general, reduced signaling through the TOR
pathway, achieved by either genetic or pharmacological means,
results in increased longevity. Two underlying mechanisms, which
are not mutually exclusive, are proposed: increased stress resistance
and increased respiration.4,5 The most well-known small molecule
inhibitor of TOR signaling is rapamycin. Rapamycin (Sirolimus)


Source: Aris, John P. - Department of Anatomy and Cell Biology, University of Florida


Collections: Biology and Medicine