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Subcellular Discharge of a Serine Protease Mediates Release of Invasive

Summary: Subcellular Discharge of a Serine
Protease Mediates Release of Invasive
Malaria Parasites from Host Erythrocytes
Sharon Yeoh,1,4 Rebecca A. O'Donnell,1,4 Konstantinos Koussis,1 Anton R. Dluzewski,1 Keith H. Ansell,2
Simon A. Osborne,2 Fiona Hackett,1 Chrislaine Withers-Martinez,1 Graham H. Mitchell,3
Lawrence H. Bannister,3 Justin S. Bryans,2 Catherine A. Kettleborough,2 and Michael J. Blackman1,*
1Division of Parasitology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
2Drug Discovery Group, Medical Research Council Technology, Mill Hill, London NW7 1AA, UK
3Guy's, King's and St. Thomas' Hospitals School of Biomedical and Life Sciences, London SE1 1UL, UK
4These authors contributed equally to this paper.
*Correspondence: mblackm@nimr.mrc.ac.uk
DOI 10.1016/j.cell.2007.10.049
The most virulent form of malaria is caused by
waves of replication of blood stages of the
protozoan pathogen Plasmodium falciparum.
The parasite divides within an intraerythrocytic
parasitophorous vacuole until rupture of the
vacuole and host-cell membranes releases
merozoites that invade fresh erythrocytes to re-


Source: Arnold, Jonathan - Nanoscale Science and Engineering Center & Department of Genetics, University of Georgia


Collections: Biotechnology