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Spontaneous Pain and Brain Activity in Neuropathic Pain: Functional MRI and

Summary: Spontaneous Pain and Brain Activity in
Neuropathic Pain: Functional MRI and
Pharmacologic Functional MRI Studies
Marwan N. Baliki, MS, Paul Y. Geha, MD, and A. Vania Apkarian, PhD
Corresponding author
A. Vania Apkarian, PhD
Northwestern University Feinberg School of Medicine,
Department of Physiology, Chicago, IL 60611, USA.
E-mail: a-apkarian@northwestern.edu
Current Pain and Headache Reports 2007, 11:171177
Current Medicine Group LLC ISSN 1531-3433
Copyright 2007 by Current Medicine Group LLC
Functional brain imaging studies in chronic neuropathic
pain patients have lagged far behind equivalent stud-
ies in acute pain. In the past few years, this trend has
begun to shift. This article discusses the novel approach
of studying brain activity for spontaneous pain and
its modulation by pharmacologic manipulation. We
argue that the approach provides a solid methodology
for studying clinical (especially neuropathic) pain and


Source: Apkarian, A. Vania - Department of Physiology, Northwestern University


Collections: Biology and Medicine