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Summary: The FASEB Journal · Research Communication
Thioredoxin-interacting protein deficiency induces
Akt/Bcl-xL signaling and pancreatic beta-cell mass
and protects against diabetes
Junqin Chen,* Simon T. Hui,
Francesca M. Couto,* Imran N. Mungrue,§
Dawn B. Davis,*,
Alan D. Attie,
Aldons J. Lusis,§
Roger A. Davis,
and
Anath Shalev*,1
*Department of Medicine and
Department of Biochemistry, University of Wisconsin, Madison,
Wisconsin, USA;
Department of Biology, San Diego State University, San Diego, California, USA;
and §
Department of Medicine, University of California, Los Angeles, California, USA
ABSTRACT Pancreatic beta-cell loss through apopto-
sis represents a key factor in the pathogenesis of
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