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Summary: Cell, Vol. 76, 1069-1099, September 23, 1994, Copyright 0 1994 by Cell Press
The A. thaliana Disease Resistance Gene RPS2
Encodes a Protein Containing
a Nucleotide-Binding Site and Leucine-Rich Repeats
Michael Mindrinos,' Fumiaki Katagiri,'
Guo-Liang Yu,t and Frederick M. Ausubei
Department of Genetics
Harvard Medical School
and Department of Molecular Biology
Massachusetts General Hospital
Boston, Massachusetts 02114
Summary
In plants, resistance to a pathogen is frequently corre-
lated with a genetically defined interaction between a
plant resistance gene and a corresponding pathogen
avirulence gene. A simple model explains these gene-
for-gene interactions: avirulence gene products gen-
erate signals (iigands), and resistance genes encode
cognate receptors. The A. thaliana RPSP gene confers
resistance to the bacterial pathogen P. syringae car-
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