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Developmental Cell, Vol. 8, 635649, May, 2005, Copyright 2005 by Elsevier Inc. DOI 10.1016/j.devcel.2005.02.014 Identification of Genes Needed for Regeneration,
 

Summary: Developmental Cell, Vol. 8, 635­649, May, 2005, Copyright ©2005 by Elsevier Inc. DOI 10.1016/j.devcel.2005.02.014
Identification of Genes Needed for Regeneration,
Stem Cell Function, and Tissue Homeostasis
by Systematic Gene Perturbation in Planaria
Peter W. Reddien, Adam L. Bermange,1,2
number of attributes not manifested by current ecdyso-
zoan model systems (e.g., C. elegans and Drosophila),Kenneth J. Murfitt,1
Joya R. Jennings,
such as regeneration and adult somatic stem cells.and Alejandro Sánchez Alvarado*
Therefore, studies of planarian biology will help the un-Department of Neurobiology and Anatomy
derstanding of processes relevant to human develop-University of Utah School of Medicine
ment and health not easily studied in current inverte-401 MREB, 20N 1900E
brate genetic systems.Salt Lake City, Utah 84132
Neoblasts are the only known proliferating cells in
adult planarians and reside in the parenchyma. Follow-
ing injury, a neoblast proliferative response is triggered,Summary
generating a regeneration blastema consisting of ini-
tially undifferentiated cells covered by epidermal cells.Planarians have been a classic model system for the
Moreover, essentially all tissues in adult planarians turnstudy of regeneration, tissue homeostasis, and stem
over and are replaced by neoblast progeny. Althoughcell biology for over a century, but they have not his-

  

Source: Alvarado, Alejandro Sánchez - Department of Neurobiology and Anatomy, University of Utah

 

Collections: Biology and Medicine