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Summary: 1000 VOLUME 42 | NUMBER 11 | NOVEMBER 2010 Nature GeNetics
l e t t e r s
Wecarriedoutameta-analysisoftworecentpsoriasis
genome-wideassociationstudies1,2withacombineddiscovery
sampleof1,831affectedindividuals(cases)and2,546controls.
OnehundredandtwolociselectedbasedonPvaluerankings
werefollowedupinathree-stagereplicationstudyincluding
4,064casesand4,685controlsfromMichigan,Toronto,
NewfoundlandandGermany.Inthecombinedmeta-analysis,
weidentifiedthreenewsusceptibilityloci,includingoneat
NOS2(rs4795067,combinedP=4×10-11),oneatFBXL19
(rs10782001,combinedP=9×10-10)andonenearPSMA6-
NFKBIA(rs12586317,combinedP=2×10-8).Allthreeloci
werealsoassociatedwithpsoriaticarthritis(rs4795067,
combinedP=1×10-5;rs10782001,combinedP=4×10-8;
andrs12586317,combinedP=6×10-5)andpurelycutaneous
psoriasis(rs4795067,combinedP=1×10-8;rs10782001,
combinedP=2×10-6;andrs12586317,combinedP=1×
10-6).Wealsoreplicatedarecentlyidentified3association
signalnearRNF114(rs495337,combinedP=2×10-7).
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