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1000 VOLUME 42 | NUMBER 11 | NOVEMBER 2010 Nature GeNetics l e t t e r s
 

Summary: 1000 VOLUME 42 | NUMBER 11 | NOVEMBER 2010 Nature GeNetics
l e t t e r s
Wecarriedoutameta-analysisoftworecentpsoriasis
genome-wideassociationstudies1,2withacombineddiscovery
sampleof1,831affectedindividuals(cases)and2,546controls.
OnehundredandtwolociselectedbasedonPvaluerankings
werefollowedupinathree-stagereplicationstudyincluding
4,064casesand4,685controlsfromMichigan,Toronto,
NewfoundlandandGermany.Inthecombinedmeta-analysis,
weidentifiedthreenewsusceptibilityloci,includingoneat
NOS2(rs4795067,combinedP=410-11),oneatFBXL19
(rs10782001,combinedP=910-10)andonenearPSMA6-
NFKBIA(rs12586317,combinedP=210-8).Allthreeloci
werealsoassociatedwithpsoriaticarthritis(rs4795067,
combinedP=110-5;rs10782001,combinedP=410-8;
andrs12586317,combinedP=610-5)andpurelycutaneous
psoriasis(rs4795067,combinedP=110-8;rs10782001,
combinedP=210-6;andrs12586317,combinedP=1
10-6).Wealsoreplicatedarecentlyidentified3association
signalnearRNF114(rs495337,combinedP=210-7).

  

Source: Abecasis, Goncalo - Department of Biostatistics, University of Michigan

 

Collections: Biology and Medicine; Mathematics