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A Metasystem of Framework Model Organisms to Study Emergence of New Host-Microbe Adaptations
 

Summary: A Metasystem of Framework Model Organisms to Study
Emergence of New Host-Microbe Adaptations
Suresh Gopalan1,2
*, Frederick M. Ausubel1,2
1 Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, 2 Department of Genetics, Harvard Medical School,
Boston, Massachusetts, United States of America
Abstract
An unintended consequence of global industrialization and associated societal rearrangements is new interactions of
microbes and potential hosts (especially mammals and plants), providing an opportunity for the rapid emergence of host-
microbe adaptation and eventual establishment of new microbe-related diseases. We describe a new model system
comprising the model plant Arabidopsis thaliana and several microbes, each representing different modes of interaction, to
study such ``maladaptations''. The model microbes include human and agricultural pathogens and microbes that are
commonly considered innocuous. The system has a large knowledge base corresponding to each component organism and
is amenable to high-throughput automation assisted perturbation screens for identifying components that modulate host-
pathogen interactions. This would aid in the study of emergence and progression of host-microbe maladaptations in a
controlled environment.
Citation: Gopalan S, Ausubel FM (2008) A Metasystem of Framework Model Organisms to Study Emergence of New Host-Microbe Adaptations. PLoS ONE 3(12):
e3891. doi:10.1371/journal.pone.0003891
Editor: Niyaz Ahmed, Centre for DNA Fingerprinting and Diagnostics, India
Received November 7, 2008; Accepted November 13, 2008; Published December 10, 2008

  

Source: Ausubel, Frederick M. - Department of Genetics, Harvard University

 

Collections: Biology and Medicine