Signal enhancement by diffusion: experimental observation of the
Luisa Ciobanua,*, Andrew G. Webba
, Charles H. Penningtonb
Biomedical Imaging Center, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, IL, USA
Department of Physics, The Ohio State University, Columbus, OH, USA
Received 3 April 2004; revised 29 June 2004
Available online 29 July 2004
Inadequate signal-to-noise ratio is a major factor limiting applications of magnetic resonance microscopy. The ``Diffusion En-
hancement of Signal and Resolution'' (DESIRE) scheme promises potential sensitivity enhancements of between one and three or-
ders of magnitude, but images using this mechanism have not been shown to date. Here, we report the first images obtained using
the DESIRE method, and obtain excellent agreement between numerical simulations and experimental data with signal-to-noise
enhancements of close to one order of magnitude.
Ó 2004 Elsevier Inc. All rights reserved.
Keywords: MR microscopy; Diffusion-enhanced MRI; Resolution; Magnetic resonance histology