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BioMed Central Page 1 of 12

Summary: BioMed Central
Page 1 of 12
(page number not for citation purposes)
BMC Developmental Biology
Open AccessResearch article
BDNF promotes target innervation of Xenopus mandibular
trigeminal axons in vivo
Jeffrey K Huang*1, Karel Dorey1,2, Shoko Ishibashi1,2 and
Enrique Amaya*1,2
Address: 1Wellcome Trust/Cancer Research UK Gurdon Institute, Tennis Court Road, University of Cambridge, Cambridge, CB2 1QR UK and 2The
Healing Foundation Centre, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
Email: Jeffrey K Huang* - jh424@cam.ac.uk; Karel Dorey - Karel.Dorey@manchester.ac.uk;
Shoko Ishibashi - Shoko.Ishibashi@manchester.ac.uk; Enrique Amaya* - Enrique.Amaya@manchester.ac.uk
* Corresponding authors Equal contributors
Background: Trigeminal nerves consist of ophthalmic, maxillary, and mandibular branches that
project to distinct regions of the facial epidermis. In Xenopus embryos, the mandibular branch of
the trigeminal nerve extends toward and innervates the cement gland in the anterior facial
epithelium. The cement gland has previously been proposed to provide a short-range
chemoattractive signal to promote target innervation by mandibular trigeminal axons. Brain derived


Source: Amaya, Enrique - Healing Foundation Centre & Developmental Biology, Faculty of Life Sciences, University of Manchester


Collections: Biology and Medicine