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Protein Tyrosine Phosphatase Gene PTPN22 Polymorphism in Psoriasis: Lack of Evidence for Association
 

Summary: Protein Tyrosine Phosphatase Gene PTPN22 Polymorphism in
Psoriasis: Lack of Evidence for Association
To the Editor:
LYP, the protein product of the protein tyrosine phosphatase
gene PTPN22 located on human chromosome 1p13.2, is
involved in downregulation of T cell signaling through its
interaction with C-terminal Src tyrosine kinase (Csk) (Clout-
ier and Veillette, 1996), by phosphorylation of regulatory ty-
rosines on the Src family kinase Lck (Cloutier and Veillette,
1999). A missense mutation of this gene (C1858T, R620W),
found in 15%17% of the Caucasian population, has been
associated with autoimmune pathology in type I diabetes
(T1D) (Bottini et al, 2004; Onengut-Gumuscu et al, 2004;
Smyth et al, 2004; Ladner et al, 2005), rheumatoid arthritis
(RA) (Begovich et al, 2004), systemic lupus erythematosus
(SLE) (Kyogoku et al, 2004), and Graves disease (GD)
(Smyth et al, 2004; Velaga et al, 2004) but not in multiple
sclerosis (Begovich et al, 2005). It has also been shown to
be functionally relevant in terms of binding to Csk (Bottini
et al, 2004) and inhibition of signalling via the T cell antigen

  

Source: Abecasis, Goncalo - Department of Biostatistics, University of Michigan

 

Collections: Biology and Medicine; Mathematics