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Integration of Caenorhabditis elegans MAPK pathways mediating immunity and stress resistance
 

Summary: Integration of Caenorhabditis elegans MAPK
pathways mediating immunity and stress resistance
by MEK-1 MAPK kinase and VHP-1 MAPK phosphatase
Dennis H. Kim*, Nicole T. Liberati*, Tomoaki Mizuno
, Hideki Inoue
, Naoki Hisamoto
, Kunihiro Matsumoto
,
and Frederick M. Ausubel*
*Department of Genetics, Harvard Medical School, and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114; and
Department of Molecular Biology, Graduate School of Science, Institute for Advanced Research, Nagoya University, and Core Research for Evolutional
Science and Technology, Japan Science and Technology Corp., Chikusa-ku, Nagoya 464-8602, Japan
Contributed by Frederick M. Ausubel, May 20, 2004
The p38 and JNK classes of mitogen-activated protein kinases
(MAPKs) have evolutionarily conserved roles in the control of
cellular responses to microbial and abiotic stresses. The mecha-
nisms by which crosstalk between distinct p38 and c-Jun N-terminal
kinase (JNK) MAPK pathways occurs with resultant integration of
signaling information have been difficult to establish, particularly
in the context of whole organism physiology. In Caenorhabditis

  

Source: Ausubel, Frederick M. - Department of Genetics, Harvard University

 

Collections: Biology and Medicine