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Nanomolar scale nitric oxide generation from self-assembled monolayer modified gold electrodes
 

Summary: Nanomolar scale nitric oxide generation from self-assembled monolayer
modified gold electrodes
Yongchun Hou, Yongsheng Chen, Nabil A. Amro, Kapila Wadu-Mesthrige, Peter R. Andreana, Gang-yu Liu
and Peng G. Wang*
Department of Chemistry, Wayne State University, Detroit, MI 48202, USA. E-mail: pwang@chem.wayne.edu
Received (in Corvallis, OR, USA) 23rd May 2000, Accepted 7th August 2000
First published as an Advance Article on the web 11th September 2000
A SAM-modified gold electrode has been developed for the
first time for quantitative NO generation of a nanomolar
amount that is proportional to the surface area of the
electrode.
Nitric oxide, a relatively unstable, potentially toxic gas, has
been implicated in a wide variety of physiological and
pathological processes.14 Considering the numerous functions
of NO in the human body, controlled delivery of a quantitative
amount of NO to specific sites is most critical for biomedical
applications of NO donor compounds.5,6 On the other hand,
extensive research on a variety of self-assembled monolayers
(SAMs) on different metal electrodes has resulted in many
biomedical applications during the past decade.711 In our

  

Source: Andreana, Peter R. - Department of Chemistry, Wayne State University

 

Collections: Chemistry