Summary: Behavioural Brain Research 170 (2006) 99109
Cooperation between the hippocampus and the entorhinal cortex
in spatial memory: A disconnection study
Carole Parron, Bruno Poucet, Etienne Save
Laboratory of Neurobiology and Cognition, UMR 6155 CNRS, Universit´e de Provence, p^ole 3C, case C, 3 place Victor Hugo, 13331 Marseille cedex 3, France
Received 3 November 2005; received in revised form 6 February 2006; accepted 9 February 2006
Available online 15 March 2006
It has been recently shown that lesions of parahippocampal areas including the entorhinal cortex do not disrupt place learning in the water
maze, suggesting that the hippocampo-cortical circuitry is not important for spatial memory [Burwell RD, Saddoris MP, Bucci DJ, Wiig KA.
Corticohippocampal contributions to spatial and contextual learning. J Neurosci 2004;24:382636]. The aim of the present study was to tax more
directly the cooperation between the hippocampus and entorhinal cortex in two different spatial tasks, a place navigation task and a spontaneous
object exploration task, using a disconnection procedure. Damaging the entorhinalhippocampal system induced impairments in the two tasks but
only in the spatial object exploration task rats with contralateral lesions displayed a greater deficit than rats with ipsilateral lesions. The results
suggest that the cooperation between the hippocampus and the entorhinal cortex is modulated by the nature of the task and the cognitive processes
involved in formation of spatial memory.
© 2006 Elsevier B.V. All rights reserved.
Keywords: Hippocampus; Entorhinal cortex; Spatial behavior; Lesion; Rat