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Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity
 

Summary: Long chain amines and long chain ammonium
salts as novel inhibitors of dynamin GTPase activity
Timothy A. Hill,a
Luke R. Odell,a
Annie Quan,b
Ruben Abagyan,c
Gemma Ferguson,a
Phillip J. Robinsonb,
and Adam McCluskeya,*
a
Advanced Synthetic Materials Group, Chemistry Building, School Environmental and Life Sciences,
The University of Newcastle, Callaghan, NSW 2308, Australia
b
Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, NSW 2145, Australia
c
Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road,
TCP-28, La Jolla, CA 92037, USA
Received 29 September 2003; accepted 29 March 2004
Abstract--We examined a number of ligands with the view of inhibiting the GTPase activity of dynamin. Dynamin contains a
pleckstrin homology (PH) domain that interacts with lipids. We report a series of simple lipid-like molecules that display moderate

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collections: Biology and Medicine