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Proc. Nadl. Acad. Sci. USA Vol. 91, pp. 11308-11312, November 1994
 

Summary: Proc. Nadl. Acad. Sci. USA
Vol. 91, pp. 11308-11312, November 1994
Neurobiology
Activity-dependent current distributions in model neurons
(activity-dependent regulation/neuronal plastcity/calcium-dependent modulation/channel density)
MICAH SIEGEL*, EVE MARDER, AND L. F. ABBOTTt
Center for Complex Systems, Brandeis University, Waltham, MA 02254
Communicated by John J. Hopfield, August 15, 1994
ABSTRACT The electrical activity of a neuron can affect
its intrinsic physiological characteristics through a wide range
of processes. We study a computer-simulated multicompart-
ment model neuron In which channel density depends on local
Ca2+ concentrations. This has three interesting consequences
for the spatial distribution of conductances and the physiolog-
ical behavior ofthe neuron: (i) the model neuron spontaneously
develops a realistic, nonuniform distribution of conductances
that is linked both to the morphology of the neuron and to the
pattern of synaptic input that it receives, (i) the response to
synaptic Input reveals a form of intrinsic localized plasticity
that balances the synaptic contribution from dendritic regions

  

Source: Abbott, Laurence - Center for Neurobiology and Behavior & Department of Physiology and Cellular Biophysics, Columbia University

 

Collections: Biology and Medicine