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Physica A 344 (2004) 543546 www.elsevier.com/locate/physa

Summary: Physica A 344 (2004) 543­546
Solute di usion out of a vesicle
Yan Levin, Marco A. Idiart, Jeferson J. Arenzon
Instituto de FÃsica, University Federal do Rio Grande do Sul, Porto Alegre RSCEP,
Caixa Postal 15051, 91501-970 Brazil
Available online 4 July 2004
Motivated by the problem of calculating the e usion time of solute from a spherical vesicle
with an open pore, we present an analytical solution of a simpler problem in which solute
particles are allowed to escape through a spherical cavity located at the center of the vesicle.
c 2004 Elsevier B.V. All rights reserved.
PACS: 66.10.Cb; 82.39.Wj; 87.16.Dg
Keywords: Di usion; E usion; Vesicle; Drug delivery; Mixed-Boundary
1. Introduction
The time of e ux of solute through an open pore of a liposomal vesicle is an
important practical problem of direct relevance to the design of e cient drug delivery
systems [1,2]. There are a number of mechanisms involved in the leak-out. The osmotic
pressure di erence between the interior and the exterior of the vesicle produces an
osmotic current through an open pore [3]. This ow also results in the transport of


Source: Arenzon, Jeferson J. - Instituto de Física, Universidade Federal do Rio Grande do Sul
Levin, Yan - Instituto de Física, Universidade Federal do Rio Grande do Sul


Collections: Physics