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Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease
 

Summary: Genetic Variants Influencing Circulating Lipid Levels and
Risk of Coronary Artery Disease
Dawn M. Waterworth, Sally L. Ricketts, Kijoung Song, Li Chen, Jing Hua Zhao, Samuli Ripatti,
Yurii S. Aulchenko, Weihua Zhang, Xin Yuan, Noha Lim, Jian'an Luan, Sofie Ashford,
Eleanor Wheeler, Elizabeth H. Young, David Hadley, John R. Thompson, Peter S. Braund,
Toby Johnson, Maksim Struchalin, Ida Surakka, Robert Luben, Kay-Tee Khaw, Sheila A. Rodwell,
Ruth J.F. Loos, S. Matthijs Boekholdt, Michael Inouye, Panagiotis Deloukas, Paul Elliott,
David Schlessinger, Serena Sanna, Angelo Scuteri, Anne Jackson, Karen L. Mohlke, Jaako Tuomilehto,
Robert Roberts, Alexandre Stewart, Y. Antero Kesa¨niemi, Robert W. Mahley, Scott M. Grundy,
Wellcome Trust Case Control Consortium, Wendy McArdle, Lon Cardon, Ge´rard Waeber,
Peter Vollenweider, John C. Chambers, Michael Boehnke, Gonc¸alo R. Abecasis, Veikko Salomaa,
Marjo-Riitta Ja¨rvelin, Aimo Ruokonen, Ine^s Barroso, Stephen E. Epstein, Hakon H. Hakonarson,
Daniel J. Rader, Muredach P. Reilly, Jacqueline C.M. Witteman, Alistair S. Hall, Nilesh J. Samani,
David P. Strachan, Philip Barter, Cornelia M. van Duijn, Jaspal S. Kooner, Leena Peltonen,
Nicholas J. Wareham, Ruth McPherson, Vincent Mooser, Manjinder S. Sandhu
Objective--Genetic studies might provide new insights into the biological mechanisms underlying lipid metabolism and
risk of CAD. We therefore conducted a genome-wide association study to identify novel genetic determinants of
low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides.
Methods and Results--We combined genome-wide association data from 8 studies, comprising up to 17 723 participants
with information on circulating lipid concentrations. We did independent replication studies in up to 37 774 participants

  

Source: Abecasis, Goncalo - Department of Biostatistics, University of Michigan

 

Collections: Biology and Medicine; Mathematics