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Refinement of Glucagon-like Peptide 1 Docking to Its Intact Receptor Using Mid-region Photolabile Probes and Molecular
 

Summary: Refinement of Glucagon-like Peptide 1 Docking to Its Intact
Receptor Using Mid-region Photolabile Probes and Molecular
Modeling*
Received for publication,December 31, 2010, and in revised form, February 22, 2011 Published, JBC Papers in Press,March 16, 2011, DOI 10.1074/jbc.M110.217901
Laurence J. Miller1
, Quan Chen
, Polo C.-H. Lam§¶
, Delia I. Pinon
, Patrick M. Sexton 2
, Ruben Abagyan§¶
,
and Maoqing Dong3
From the
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, Arizona 85259, the
§
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California 92037,

Molsoft LLC, La Jolla, California 92037, and the Drug Discovery Biology Laboratory, Monash Institute of Pharmaceutical Sciences,
and Department of Pharmacology, Monash University, Parkville 3052, Victoria, Australia
The glucagon-like peptide 1 (GLP1) receptor is an important

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collections: Biology and Medicine