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Summary: Refinement of Glucagon-like Peptide 1 Docking to Its Intact
Receptor Using Mid-region Photolabile Probes and Molecular
Modeling*
Received for publication,December 31, 2010, and in revised form, February 22, 2011 Published, JBC Papers in Press,March 16, 2011, DOI 10.1074/jbc.M110.217901
Laurence J. Miller1
, Quan Chen
, Polo C.-H. Lam§¶
, Delia I. Pinon
, Patrick M. Sexton 2
, Ruben Abagyan§¶
,
and Maoqing Dong3
From the
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, Arizona 85259, the
§
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California 92037,
¶
Molsoft LLC, La Jolla, California 92037, and the Drug Discovery Biology Laboratory, Monash Institute of Pharmaceutical Sciences,
and Department of Pharmacology, Monash University, Parkville 3052, Victoria, Australia
The glucagon-like peptide 1 (GLP1) receptor is an important
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