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TheJournalofExperimentalMedicine The Rockefeller University Press $30.00
 

Summary: TheJournalofExperimentalMedicine
The Rockefeller University Press $30.00
J. Exp. Med. Vol. 205 No. 9 1949-1957
www.jem.org/cgi/doi/10.1084/jem.20081007
1949
BRIEF DEFINITIVE REPORT
Upon antigen encounter, activated B cells of-
ten replace their heavy chain constant domain
(C ) with one of a set of downstream CH ex-
ons (C , C , or C ) in a process known as
class switch recombination (CSR). This intra-
chromosomal recombination event occurs be-
tween highly repetitive switch (S) sequences
located upstream of each CH gene, with the
exception of C . CSR is targeted to specific S
regions by 5 I promoters that mediate germ-
line or sterile S-CH transcription (1), and by 5
and 3 heavy chain enhancers that promote S-S
synapses (2). These mechanisms cooperate to
render S domains accessible to activation-in-

  

Source: Alt,, Frederick - Immune Disease Institute, Harvard University

 

Collections: Biology and Medicine