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International Immunology, Vol. 8, No 1, pp 143-151 1996 Oxford University Press APC from mice harbouring the filarial
 

Summary: International Immunology, Vol. 8, No 1, pp 143-151 1996 Oxford University Press
APC from mice harbouring the filarial
nematode, Brugia malayi, prevent cellular
proliferation but not cytokine production
Judith E. Allen, Rachel A. Lawrence1
and Rick M. Maizels
Institute of Cell, Animal and Population Biology, Ashworth Laboratories, University of Edinburgh,
Edinburgh EH9 3JT, UK
department of Biology, Imperial College, London SW7 2BB, UK
Keywords anergy, lymphatic filariasis, macrophage, suppression, T cells
Abstract
Specific T cell hyporesponsiveness and depressed antibody production is a key feature of human
infection with the filarial nematodes, Brugia malayi and Wuchereria bancrofti. Despite this immune
suppression, responses indicative of Th2 subset activation are present, including unusually high
levels of specific lgG4. We tested the possibility that infection with filarial nematodes causes a
reduction in the co-stimulatory or antigen-presenting capacity of macrophages resulting in a failure
to activate specific T cells. Adherent peritoneal exudate cells (PEC) from mice implanted with adult
B. malayi were used to present antigen to the conalbumin-specific T cell clone, D10.G4.
Proliferation of the D10 cells at even background levels was completely blocked by the presence of
implant-derived adherent PEC. However, cytokine production by these cells in response to antigen

  

Source: Allen, Judith - School of Biological Sciences, University of Edinburgh

 

Collections: Biology and Medicine