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INTRODUCTION We used spared nerve injury (SNI)
 

Summary: INTRODUCTION
We used spared nerve injury (SNI)
neuropathic rats and followed their
mechanical (Von Frey filaments test), cold
(acetone test) allodynia, and paw position
(score from 0 to 4 an index of the intensity of
the protective behavior) responses following
treatment with D-cycloserine.
D-cycloserine was applied either
(Exp. 1) Once orally (0, 3, 10 or 30
mg/kg),
(Exp. 2) once intrathecally (0, 10 or 50
microg/rat), or
(Exp. 3) for 2 weeks orally (twice daily;
saline, 3, 10 or 30 mg/kg). After 3 weeks of
stopping treatment, rats received a second 2-
week oral treatment.
(Exp. 4) Orally until the allodynia plateaus
(twice daily, saline or 30 mg/kg). Response
timecourse followed during and after

  

Source: Apkarian, A. Vania - Department of Physiology, Northwestern University

 

Collections: Biology and Medicine