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Summary: Network model of survival signaling in large granular
lymphocyte leukemia
Ranran Zhang
, Mithun Vinod Shah
, Jun Yang
, Susan B. Nyland
, Xin Liu
, Jong K. Yun
, Re´ka Albert§¶
,
and Thomas P. Loughran, Jr.
Penn State Hershey Cancer Institute and Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA 17033;
and §Department of Physics, The Pennsylvania State University, University Park, PA 16802
Edited by Wayne M. Yokoyama, Washington University School of Medicine, St. Louis, MO, and approved September 4, 2008 (received for review
July 5, 2008)
T cell large granular lymphocyte (T-LGL) leukemia features a clonal
expansion of antigen-primed, competent, cytotoxic T lymphocytes
(CTL). To systematically understand signaling components that
determine the survival of CTL in T-LGL leukemia, we constructed a
T-LGL survival signaling network by integrating the signaling
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