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Substantial Regional Variation in Substitution Rates in the Human Genome: Importance of GC Content, Gene Density, and Telomere-Specific Effects
 

Summary: Substantial Regional Variation in Substitution Rates in the Human Genome:
Importance of GC Content, Gene Density, and Telomere-Specific Effects
Peter F. Arndt,1
Terence Hwa,2
Dmitri A. Petrov3
1
Max Planck Institute for Molecular Genetics, Ihnestr. 73, 14195 Berlin, Germany
2
Department of Physics and Center for Theoretical Biological Physics, UC San Diego, 9500 Gilman Drive, La Jolla, CA 93092-0374, USA
3
Department of Biological Sciences, 371 Serra Street, Stanford University, Stanford, CA 94305, USA
Received: 20 July 2004 / Accepted: 30 December 2004 [Reviewing Editor: Dr. Jerzy Jurka]
Abstract. This study presents the first global, 1-
Mbp-level analysis of patterns of nucleotide substi-
tutions along the human lineage. The study is based
on the analysis of a large amount of repetitive ele-
ments deposited into the human genome since the
mammalian radiation, yielding a number of results
that would have been difficult to obtain using the
more conventional comparative method of analysis.

  

Source: Arndt, Peter - Max-Planck-Institut für molekulare Genetik
Petrov, Dmitri - Department of Biology, Stanford University
Spang, Rainer - Computational Molecular Biology Group, Max-Planck-Institut für molekulare Genetik

 

Collections: Biology and Medicine; Biotechnology; Computer Technologies and Information Sciences; Physics