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Phase Separation in Bilayer Lipid Membranes: Effects on the Inner Leaf due to Coupling to the
 

Summary: Phase Separation in Bilayer Lipid Membranes:
Effects on the Inner Leaf due to Coupling to the
Outer Leaf
D.W. Allender
Department of Physics and Liquid Crystal Institute
Kent State University, Kent OH 44242
M. Schick
Department of Physics
University of Washington, Box 351560, Seattle, WA 98195-1560
April 11, 2006, draft
Abstract
We investigate the combined effects of the tendency of cholesterol to order
lipids in the liquid phase and the coupling between lipids in the two leaves
of a bilayer. We show that as a consequence of this coupling, lateral phase
separation in the outer leaf between cholesterol-rich and -poor liquids causes
a similar, but weaker, phase separation in the inner leaf. Just as the areal
density of lipids in the outer leaf increases in the cholesterol-rich regions, so
the areal density of lipids also increases in the inner leaf. Thus the areal
density in the inner leaf varies spatially, reflecting spatial variations of the
areal density in the outer leaf. This provides a mechanism for proteins

  

Source: Allender, David W. - Department of Physics, Kent State University

 

Collections: Physics