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Journal of Neuroscience Methods 163 (2007) 321325 A chronically implantable, hybrid cannulaelectrode device for

Summary: Journal of Neuroscience Methods 163 (2007) 321­325
A chronically implantable, hybrid cannula­electrode device for
assessing the effects of molecules on electrophysiological
signals in freely behaving animals
Bradley Gregera,b,,1, Babak Katebc,d,1, Peter Gruenc, Paul H. Pattersonb
a University of Utah, Department of Bioengineering, Salt Lake City, UT 84112, United States
b California Institute of Technology, Division of Biology, Pasadena, CA 91125, United States
c USC-Keck School of Medicine, Department of Neurological Surgery, Los Angeles, CA 90033, United States
d City of Hope National Comprehensive Cancer Center, Brain Tumor Program, Duarte, CA 90101, United States
Received 29 January 2006; received in revised form 22 March 2007; accepted 23 March 2007
We describe a device for assessing the effects of diffusible molecules on electrophysiological recordings from multiple neurons. This device
allows for the infusion of reagents through a cannula located among an array of micro-electrodes. The device can easily be customized to target
specific neural structures. It is designed to be chronically implanted so that isolated neural units and local field potentials are recorded over the
course of several weeks or months. Multivariate statistical and spectral analysis of electrophysiological signals acquired using this system could
quantitatively identify electrical "signatures" of therapeutically useful drugs.
Published by Elsevier B.V.
Keywords: Drug delivery; Single-unit recording; Local field potential recording; Drug screening; Neural prosthetics
1. Introduction
For many decades, animal models have been used for the


Source: Andersen, Richard - Division of Biology, California Institute of Technology


Collections: Biology and Medicine