ATTENTION PHARMACIST: Detach "Patient's Instructions for Use" from package insert
and dispense with product.
FOR ORAL INHALATION ONLY
SPIRIVA« HandiHaler« (tiotropium bromide inhalation powder) consists of a capsule dosage
form containing a dry powder formulation of SPIRIVA intended for oral inhalation only with the
HandiHaler inhalation device.
Each light green, hard gelatin capsule contains 18 mcg tiotropium (equivalent to 22.5 mcg
tiotropium bromide monohydrate) blended with lactose monohydrate as the carrier.
The dry powder formulation within the capsule is intended for oral inhalation only.
The active component of SPIRIVA is tiotropium. The drug substance, tiotropium bromide
monohydrate, is an anticholinergic with specificity for muscarinic receptors. It is chemically
described as (1, 2▀, 4▀, 5, 7▀)-7-[(Hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-