Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
Water film thickness-dependent conformation and diffusion of single-strand DNA on poly,,ethylene glycol...-silane surface
 

Summary: Water film thickness-dependent conformation and diffusion of
single-strand DNA on poly,,ethylene glycol...-silane surface
Jae Hyun Park and N. R. Alurua
Department of Mechanical Science and Engineering, Beckman Institute for Advanced Science and
Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
Received 26 December 2009; accepted 24 February 2010; published online 24 March 2010
In this paper, we investigate, using molecular dynamics simulations, the conformation and diffusion
of longer and shorter single-strand DNA ssDNA as a function of water film thickness. While the
conformation of the shorter ssDNA is significantly affected and the diffusion is suppressed with
reduction in water film thickness, the conformation and diffusion of the longer DNA is not
influenced. We explain our observations by considering the competition between stacking
interaction of bases and solvation tendency of ssDNA. This paper suggests an approach to control
the surface motion of ssDNA in nanoscale water films using film thickness. 2010 American
Institute of Physics. doi:10.1063/1.3366725
DNA separation is an essential technique for gene se-
quencing and DNA fingerprinting. The development of accu-
rate and versatile DNA separation technique is currently a
significant issue in nanobiotechnology.1
Recently, Pernodet
et al.2

  

Source: Aluru, Narayana R. - Department of Mechanical and Industrial Engineering, University of Illinois at Urbana-Champaign

 

Collections: Engineering; Materials Science