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Synapse Distribution Suggests a Two-Stage Model of Dendritic Integration

Summary: Neuron
Synapse Distribution Suggests
a Two-Stage Model of Dendritic Integration
in CA1 Pyramidal Neurons
Yael Katz,1,2 Vilas Menon,3 Daniel A. Nicholson,1,5 Yuri Geinisman,5 William L. Kath,1,3,4 and Nelson Spruston1,*
1Department of Neurobiology and Physiology
2Interdepartmental Biological Sciences Program
3Department of Engineering Sciences and Applied Mathematics
4Northwestern Institute on Complex Systems
Northwestern University, Evanston, IL 60208, USA
5Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
*Correspondence: spruston@northwestern.edu
DOI 10.1016/j.neuron.2009.06.023
Competing models have been proposed to explain
how neurons integrate the thousands of inputs dis-
tributed throughout their dendritic trees. In a simple
global integration model, inputs from all locations
sum in the axon. In a two-stage integration model,


Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago
Spruston, Nelson - Department of Neurobiology and Physiology, Northwestern University


Collections: Biology and Medicine