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Application of complex demodulation on bZIP and bHLH-PAS protein domains
 

Summary: Application of complex demodulation on bZIP and
bHLH-PAS protein domains
Zhi Wang a
, Charles E. Smith a,*, William R. Atchley a,b
a
Graduate Program in Biomathematics, North Carolina State University, Raleigh, NC 27695-8203, USA
b
Department of Genetics and Center for Computational Biology, North Carolina State University,
Raleigh, NC 27695-8203, USA
Received 21 July 2006; received in revised form 29 December 2006; accepted 10 January 2007
Available online 3 February 2007
Abstract
Proteins are built with molecular modular building blocks such as an a-helix, b-sheet, loop region and
other structures. This is an economical way of constructing complex molecules. Periodicity analysis of pro-
tein sequences has allowed us to obtain meaningful information concerning their structure, function and
evolution. In this work, complex demodulation (CDM) is introduced to detect functional regions in protein
sequences data. More specifically, we analyzed bZIP and bHLH-PAS protein domains. Complex demod-
ulation provided insightful information about changing amplitudes of periodic components in protein
sequences. Furthermore, it was found that the local amplitude minimum or local amplitude maximum
of the 3.6-aa periodic component is associated with protein structural or functional information due to

  

Source: Atchley, William R.- Department of Genetics, North Carolina State University

 

Collections: Biology and Medicine