Summary: Nature GeNetics VOLUME 43 | NUMBER 4 | APRIL 2011 339
Genome-wideassociationstudieshaveidentified11common
variantsconvincinglyassociatedwithcoronaryartery
disease(CAD)1­7,amodestnumberconsideringtheapparent
heritabilityofCAD8.Allofthesevariantshavebeendiscovered
inEuropeanpopulations.Wereportameta-analysisoffour
largegenome-wideassociationstudiesofCAD,with~575,000
genotypedSNPsinadiscoverydatasetcomprising15,420
individualswithCAD(cases)(8,424Europeansand6,996
SouthAsians)and15,062controls.Therewaslittleevidence
forancestry-specificassociations,supportingtheuseof
combinedanalyses.Replicationinanindependentsampleof
21,408casesand19,185controlsidentifiedfivelocinewly
associatedwithCAD(P<5×10-8inthecombineddiscovery
andreplicationanalysis):LIPAon10q23,PDGFDon11q22,
ADAMTS7-MORF4L1on15q25,agenerichlocuson7q22
andKIAA1462on10p11.TheCAD-associatedSNPinthe
PDGFDlocusshowedtissue-specificcisexpressionquantitative
traitlocuseffects.Thesefindingsimplicatenewpathways
forCADsusceptibility.

Source: Abecasis, Goncalo - Department of Biostatistics, University of Michigan

Collections: Biology and Medicine; Mathematics