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B I E N N I A L R E P O R T 2 0 0 8 -2 0 0 9B I O Z E N T R U M , U N I V E R S I T Y O F B A S E L 12 G R O W T H & D E V E L O P M E N T
 

Summary: B I E N N I A L R E P O R T 2 0 0 8 - 2 0 0 9B I O Z E N T R U M , U N I V E R S I T Y O F B A S E L 12
G R O W T H & D E V E L O P M E N T
Cell signalling and cell rearrangement during
organ morphogenesis
The organization of body pattern in developing multi-cellular
organisms is controlled to a large extent by cell-cell
signaling. In the past two decades, the molecular
components of a relatively small number of diverse
developmental signaling cascades conserved throughout
evolution have been identified. We have been studying two
important developmental signals (Dpp/BMP and Fgf), and
our efforts concentrated firstly on characterizing the
signaling pathways in detail and deciphering their molecular
logic, and secondly on understanding how these pathways
control exquisite cellular behavior during development,
both in Drosophila and in zebrafish. Our most intense
research efforts are directed towards a profound
understanding of cell behavior in branching morphogenesis,
a process that leads to the ramification of epithelial
structures such as seen in the lung, the kidney, many

  

Source: Amrhein, Valentin - Zoologisches Institut, Universitšt Basel

 

Collections: Environmental Sciences and Ecology