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Copyright 2006 by the Genetics Society of America DOI: 10.1534/genetics.106.062760

Summary: Copyright 2006 by the Genetics Society of America
DOI: 10.1534/genetics.106.062760
Selection, Recombination and Demographic History in Drosophila miranda
Doris Bachtrog1
and Peter Andolfatto
Division of Biological Sciences, University of California, San Diego, California 92093
Manuscript received June 28, 2006
Accepted for publication September 14, 2006
Selection, recombination, and the demographic history of a species can all have profound effects on
genomewide patterns of variability. To assess the impact of these forces in the genome of Drosophila
miranda, we examine polymorphism and divergence patterns at 62 loci scattered across the genome. In
accordance with recent findings in D. melanogaster, we find that noncoding DNA generally evolves more
slowly than synonymous sites, that the distribution of polymorphism frequencies in noncoding DNA is
significantly skewed toward rare variants relative to synonymous sites, and that long introns evolve
significantly slower than short introns or synonymous sites. These observations suggest that most
noncoding DNA is functionally constrained and evolving under purifying selection. However, in contrast
to findings in the D. melanogaster species group, we find little evidence of adaptive evolution acting on
either coding or noncoding sequences in D. miranda. Levels of linkage disequilibrium (LD) in D. miranda
are comparable to those observed in D. melanogaster, but vary considerably among chromosomes. These


Source: Andolfatto, Peter - Department of Ecology and Evolutionary Biology, Princeton University


Collections: Biology and Medicine