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Wednesday Sep 05 2007 01:36 PM, JID, v196n8, 37968, PFR/VMMTNF-a Modulates Immunity to B. pertussis JID 2007:196 (15 October) CHECKED 1 M A J O R A R T I C L E
 

Summary: Wednesday Sep 05 2007 01:36 PM, JID, v196n8, 37968, PFR/VMMTNF-a Modulates Immunity to B. pertussis · JID 2007:196 (15 October) · CHECKED 1
M A J O R A R T I C L E
Delayed Role of Tumor Necrosis Factor­a in
Overcoming the Effects of Pertussis Toxin
Daniel N. Wolfe,1
Paul B. Mann,1,a
Anne M. Buboltz,2
and Eric T. Harvill1
Departments of 1
Veterinary and Biomedical Sciences and 2
Biochemistry and Molecular Biology, Pennsylvania State University, Paul M. Althouse
Laboratory, University Park
Bordetella pertussis causes whooping cough, an endemic respiratory disease that is increasing in prevalence
despite vaccination efforts. Although host immunity is modulated by virulence factors of this pathogen, it is
unclear what host factors are required to overcome their effects. Here, we investigate an apparent relationship
between the effects of pertussis toxin and tumor necrosis factor (TNF)­a. B. pertussis grows efficiently and
causes moderate pathology in wild-type mice, whereas TNF-a /
mice have higher numbers of bacteria and
leukocytes in lungs, experience more airway resistance, and die of the infection. Interestingly, an isogenic B.
pertussis strain lacking pertussis toxin did not induce these effects in TNF-a /

  

Source: Andrews, Anne M. - Huck Institutes of the Life Sciences, Pennsylvania State University

 

Collections: Biology and Medicine