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The Rockefeller University Press $30.00 J. Exp. Med. Vol. 207 No. 6 1145-1152
 

Summary: The Rockefeller University Press $30.00
J. Exp. Med. Vol. 207 No. 6 1145-1152
www.jem.org/cgi/doi/10.1084/jem.20091245
1145
Brief Definitive Report
The actin cytoskeleton is essential for proper
functioning of the immune system by regulat-
ing cell movement, cell­cell interactions, cell
signaling, and cell division. The Wiskott-Aldrich
syndrome protein (WASP) is uniquely expressed
in hematopoietic cells and is a key organizer of
cell shape through coordination of receptor sig-
naling to remodeling of the actin cytoskeleton.
WASP is critically dependent on its structural
conformation and is thought to reside in an
inactive form in the cytoplasm caused by an
intramolecular interaction between the GTPase
binding domain and the C-terminal verprolin-
cofilin-acidic domain (Kim et al., 2000). Binding
of WASP-interacting proteins such as Cdc42

  

Source: Alt,, Frederick - Immune Disease Institute, Harvard University

 

Collections: Biology and Medicine