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J Physiol 588.1 (2010) pp 9399 93 SYMPOSIUM REVIEW
 

Summary: J Physiol 588.1 (2010) pp 9399 93
SYMPOSIUM REVIEW
Activity-dependent synaptic plasticity of NMDA receptors
Nelson Rebola, Bettadapura N. Srikumar and Christophe Mulle
Laboratoire `Physiologie Cellulaire de la Synapse', CNRS, Bordeaux Neuroscience Institute, University of Bordeaux, 33077 Bordeaux Cedex, France
Activity-dependent, bidirectional control of synaptic efficacy is thought to contribute to many
forms of experience-dependent plasticity, including learning and memory. Although most
excitatory synapses contain both AMPA and N-methyl-d-aspartate receptors (AMPARs and
NMDARs), most studies have focused on the plasticity of synaptic AMPARs, and on the pivotal
role of NMDA receptors for its induction. Here we review evidence that synaptic NMDARs
themselves are subject to long-term activity-dependent changes by mechanisms that may differ
from that of synaptic AMPARs. The bidirectional modulation of NMDAR-mediated synaptic
responses is likely to have important functional implications for NMDAR-dependent forms of
synaptic plasticity.
(Received 27 July 2009; accepted after revision 5 October 2009; first published online 12 October 2009)
Corresponding author C. Mulle: Laboratoire `Physiologie Cellulaire de la Synapse', CNRS, Bordeaux Neuroscience
Institute, University of Bordeaux, 33077 Bordeaux Cedex, France. Email: mulle@u-bordeaux2.fr
Introduction
In the central nervous system, activity-dependent
bidirectional control of synaptic efficacy, as exemplified

  

Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago

 

Collections: Biology and Medicine