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Globalization and the population structure of Toxoplasma gondii
 

Summary: Globalization and the population structure
of Toxoplasma gondii
Tovi Lehmann*
, Paula L. Marcet*, Doug H. Graham*
, Erica R. Dahl*
, and J. P. Dubey**
*Division of Parasitic Diseases, Centers for Disease Control and Prevention, 4770 Buford Highway, Chamblee, GA 30341; Laboratory of Malaria and Vector
Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, MD 20852; and **Animal
Parasitic Diseases Laboratory, Animal and Natural Resources Institute, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, MD 20705
Edited by Francisco J. Ayala, University of California, Irvine, CA, and approved May 30, 2006 (received for review February 21, 2006)
Toxoplasma gondii is a protozoan parasite that infects nearly all
mammal and bird species worldwide. Usually asymptomatic, tox-
oplasmosis can be severe and even fatal to many hosts, including
people. Elucidating the contribution of genetic variation among
parasites to patterns of disease transmission and manifestations
has been the goal of many studies. Focusing on the geographic
component of this variation, we show that most genotypes are
locale-specific, but some are found across continents and are
closely related to each other, indicating a recent radiation of a
pandemic genotype. Furthermore, we show that the geographic

  

Source: Arnold, Jonathan - Nanoscale Science and Engineering Center & Department of Genetics, University of Georgia

 

Collections: Biotechnology