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Oogenesis: Prospects and Challenges for the Future
 

Summary: Oogenesis: Prospects and
Challenges for the Future
P. RODRIGUES,1,3
D. LIMBACK,1
L. MCGINNIS,1
C.E. PLANCHA,3
AND D.F. ALBERTINI1,2*
1
Department Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas
2
Marine Biological Laboratories, Woods Hole, Massachusetts
3
Unidade de Biologia da Reproduc¸a~o, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa,
Lisbon, Portugal
Oogenesis serves a singular role in the reproductive success of plants andanimals. Of their remarkable differentiation pathway what stands
out is the ability of oocytes to transform from a single cell into the totipotent lineages that seed the early embryo. As our understanding
that commonalities between diverse organisms at the genetic, cellular and molecular levels are conserved to achieve successful
reproduction, the notion that embryogenesis presupposes oogenesis has entered the day-to-day parlance of regenerative medicine and
stem cell biology. With emphasis on the mammalian oocyte, this review will cover (1) current concepts regarding the birth, survival and
growth of oocytes that depends on complex patterns of cell communication between germ line and soma, (2) the notion of ``maternal

  

Source: Albertini, David - Center for Reproductive Sciences, University of Kansas

 

Collections: Biology and Medicine