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Summary: Deceiving Others: Distinct Neural Responses
of the Prefrontal Cortex and Amygdala in Simple
Fabrication and Deception with Social Interactions
Nobuhito Abe, Maki Suzuki, Etsuro Mori, Masatoshi Itoh,
and Toshikatsu Fujii
Abstract
& Brain mechanisms for telling lies have been investigated re-
cently using neuroimaging techniques such as functional mag-
netic resonance imaging and positron emission tomography.
Although the advent of these techniques has gradually enabled
clarification of the functional contributions of the prefrontal
cortex in deception with respect to executive function, the
specific roles of subregions within the prefrontal cortex and
other brain regions responsible for emotional regulation or
social interactions during deception are still unclear. Assum-
ing that the processes of falsifying truthful responses and de-
ceiving others are differentially associated with the activities
of these regions, we conducted a positron emission tomog-
raphy experiment with 2 (truth, lie) Â 2 (honesty, dishonesty)
factorial design. The main effect of falsifying the truthful re-
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