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Behavioral/Systems/Cognitive A Comparison of Vestibular Spatiotemporal Tuning in
 

Summary: Behavioral/Systems/Cognitive
A Comparison of Vestibular Spatiotemporal Tuning in
Macaque Parietoinsular Vestibular Cortex, Ventral
Intraparietal Area, and Medial Superior Temporal Area
Aihua Chen,1 Gregory C. DeAngelis,1,2* and Dora E. Angelaki1*
1Department of Anatomy & Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110, and 2Department of Brain and Cognitive
Sciences, Center for Visual Science, University of Rochester, New York 14627
Vestibular responses have been reported in the parietoinsular vestibular cortex (PIVC), the ventral intraparietal area (VIP), and the
dorsal medial superior temporal area (MSTd) of macaques. However, differences between areas remain largely unknown, and it is not
clearwhetherthereisahierarchyincorticalvestibularprocessing.Weexaminethespatiotemporalcharacteristicsofmacaquevestibular
responses to translational motion stimuli using both empirical and model-based analyses. Temporal dynamics of direction selectivity
weresimilaracrossareas,althoughtherewasagradualshiftinthetimeofpeakdirectionaltuning,withresponsesinMSTdtypicallybeing
delayedby100150msrelativetoresponsesinPIVC(VIPwasintermediate).Responsesasafunctionofbothstimulusdirectionandtime
were fit with a spatiotemporal model consisting of separable spatial and temporal response profiles. Temporal responses were charac-
terized by a Gaussian function of velocity, a weighted sum of velocity and acceleration, or a weighted sum of velocity, acceleration, and
position. Velocity and acceleration components contributed most to response dynamics, with a gradual shift from acceleration domi-
nance in PIVC to velocity dominance in MSTd. The position component contributed little to temporal responses overall, but was
substantially larger in MSTd than PIVC or VIP. The overall temporal delay in model fits also increased substantially from PIVC to VIP to
MSTd. This gradual transformation of temporal responses suggests a hierarchy in cortical vestibular processing, with PIVC being most
proximal to the vestibular periphery and MSTd being most distal.

  

Source: Angelaki, Dora - Department of Anatomy and Neurobiology, Washington University in St. Louis
DeAngelis, Gregory - Department of Brain and Cognitive Sciences, University of Rochester

 

Collections: Biology and Medicine