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Molecular Biology of the Cell Vol. 10, 43694384, December 1999

Summary: Molecular Biology of the Cell
Vol. 10, 43694384, December 1999
Modulation of Endocytic Traffic in Polarized
Madin-Darby Canine Kidney Cells by the Small
GTPase RhoA
Som-Ming Leung,* Raul Rojas,* Christopher Maples,* Christopher Flynn,*
Wily G. Ruiz,* Tzuu-Shuh Jou,
and Gerard Apodaca*
*Renal-Electrolyte Division of the Department of Medicine, Laboratory of Epithelial Biology, and
Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261;
Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University,
Taipei, 100 Taiwan
Submitted June 7, 1999; Accepted September 15, 1999
Monitoring Editor: Suzanne R. Pfeffer
Efficient postendocytic membrane traffic in polarized epithelial cells is thought to be regulated in
part by the actin cytoskeleton. RhoA modulates assemblies of actin in the cell, and it has been
shown to regulate pinocytosis and phagocytosis; however, its effects on postendocytic traffic are
largely unexplored. To this end, we expressed wild-type RhoA (RhoAWT), dominant active RhoA
(RhoAV14), and dominant inactive RhoA (RhoAN19) in Madin-Darby canine kidney (MDCK)


Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh


Collections: Biology and Medicine