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0013-7227/95/$03.00/O Endocrinology
 

Summary: 0013-7227/95/$03.00/O
Endocrinology
Copyright 0 1995 by The Endocrine Society
Vol. 136, No. 4
Printed in USA
Down-Regulation of the Gonadotropin-Releasing
Hormone Receptor Messenger Ribonucleic Acid by
Activation of Adenylyl Cyclase in aT3-1 Pituitary
Gonadotrope Cells*
ELAINE T. ALARID? AND PAMELA L. MELLON
Departments of Reproductive Medicine and Neuroscience and the Center For Molecular Genetics,
University of California-San Diego, La Jolla, California 92093-0674
ABSTRACT
Pituitary regulation of reproductive processes depends on the sen-
sitivity of gonadotrope cells to both positive and negative regulators.
Hypothalamic GnRH is the primary stimulus for gonadotropin syn-
thesis and secretion. Therefore, the ability of the gonadotrope to
respond to GnRH and the status of GnRH receptors (GnRH-R) are
critical in the control of reproduction. In the present study, we address
the role of GnRH and two second messenger activators, a phorbol ester

  

Source: Alarid, Elaine T. - Molecular and Cellular Pharmacology Training Program & Department of Oncology,University of Wisconsin at Madison

 

Collections: Biology and Medicine