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Summary: Conjugating Berberine to a Multidrug
Resistance Pump Inhibitor Creates an
Effective Antimicrobial
Anthony R. Ball
, Gabriele Casadei
, Siritron Samosorn
, John B. Bremner,
*, Frederick M. Ausubel§
,
Terence I. Moy§
, and Kim Lewis,
*
Department of Biology and Antimicrobial Discovery Center, Northeastern University, Boston, Massachusetts 02115,
Institute for
Biomolecular Science and Department of Chemistry, University of Wollongong, Wollongong, New South Wales 2522, Australia, and
§
Department of Genetics, Harvard Medical School, and Department of Molecular Biology, Massachusetts General Hospital, Boston,
Massachusetts 02114
ABSTRACT In bacteria, multidrug-resistance pumps (MDRs) confer resistance to
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