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Summary: Genome-wide Analysis of ARS (Autonomously Replicating Sequence)
Binding Factor 1 (Abf1p)-mediated Transcriptional Regulation in
Saccharomyces cerevisiae*S
Received for publication, May 10, 2004, and in revised form, June 4, 2004
Published, JBC Papers in Press, June 10, 2004, DOI 10.1074/jbc.M405156200
Tsuyoshi Miyake, Justin Reese, Christian M. Loch, David T. Auble, and Rong Li
From the Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia,
Charlottesville, Virginia 22908-0733
Autonomously replicating sequence-binding factor-1
(Abf1p) is an essential sequence-specific transcription
factor in Saccharomyces cerevisiae that participates in
multiple nuclear events including DNA replication,
transcription activation, and gene silencing. Numerous
gene-specific analyses have implicated Abf1p in the
transcriptional control of genes involved in a diverse
range of cellular functions, leading to the notion that
Abf1p acts as a global transcriptional regulator. Here we
report findings from a genome-wide comparison of the
gene expression profiles in the wild-type and abf1-1 tem-
perature-sensitive mutant. The study identifies a total
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