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Bordetella pertussis Infection or Vaccination Substantially Protects Mice against B. bronchiseptica
 

Summary: Bordetella pertussis Infection or Vaccination
Substantially Protects Mice against B. bronchiseptica
Infection
Elizabeth M. Goebel1,2
, Xuqing Zhang1,3
, Eric T. Harvill1
*
1 Department of Veterinary and Biomedical Sciences, the Pennsylvania State University, University Park, Pennsylvania, United States of America, 2 Graduate Program in
Immunology and Infectious Diseases, the Pennsylvania State University, University Park, Pennsylvania, United States of America, 3 Graduate Program in Genetics, the
Pennsylvania State University, University Park, Pennsylvania, United States of America
Abstract
Although B. bronchiseptica efficiently infects a wide range of mammalian hosts and efficiently spreads among them, it is
rarely observed in humans. In contrast to the many other hosts of B. bronchiseptica, humans are host to the apparently
specialized pathogen B. pertussis, the great majority having immunity due to vaccination, infection or both. Here we explore
whether immunity to B. pertussis protects against B. bronchiseptica infection. In a murine model, either infection or
vaccination with B. pertussis induced antibodies that recognized antigens of B. bronchiseptica and protected the lower
respiratory tract of mice against three phylogenetically disparate strains of B. bronchiseptica that efficiently infect naišve
animals. Furthermore, vaccination with purified B. pertussis-derived pertactin, filamentous hemagglutinin or the human
acellular vaccine, Adacel, conferred similar protection against B. bronchiseptica challenge. These data indicate that individual
immunity to B. pertussis affects B. bronchiseptica infection, and suggest that the high levels of herd immunity against B.

  

Source: Andrews, Anne M. - Huck Institutes of the Life Sciences, Pennsylvania State University

 

Collections: Biology and Medicine