Summary: Modeling signal transduction
Receptor - ligand binding - assumed to be elementary reaction
Methylation, phosphorylation reactions catalyzed by enzymes,
Michaelis-Menten kinetics assumed
Dephosphorylation, protein degradation spontaneous or catalyzed
Protein synthesis catalyzed by mRNA
Continuous and deterministic models.
Steps: Designate one component as signal and one as response;
Write rates of change for the concentration of components;
Find steady state concentrations;
Determine the dependence of the steady state response on the
J. Tyson, K. Chen, B. Novak, Curr. Opin. Cell Biology 15, 221 (2003)
The signal acts on R both directly, and through an intermediary. S
is assumed to work at saturation (plentiful substrate). The catalyzed
decay is assumed to be elementary.