Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
Proc. Natl. Acad. Sci. USA Vol. 94, pp. 59295933, May 1997
 

Summary: Proc. Natl. Acad. Sci. USA
Vol. 94, pp. 5929­5933, May 1997
Neurobiology
Selective enhancement of emotional, but not motor, learning in
monoamine oxidase A-deficient mice
(amygdala norepinephrine serotonin cerebellum mutant mice)
JEANSOK J. KIM*, JEAN C. SHIH, KEVIN CHEN, LU CHEN*, SHAOWEN BAO*, STEPHEN MAREN§,
STEPHAN G. ANAGNOSTARAS§, MICHAEL S. FANSELOW§, EDWARD DE MAEYER¶, ISABELLE SEIF¶,
AND RICHARD F. THOMPSON*
*Neuroscience Program, University of Southern California, Los Angeles, CA 90089-2520; Department of Molecular Pharmacology and Toxicology, University of
Southern California, Los Angeles, CA 90033; §Department of Psychology, University of California, Los Angeles, CA 90024-1563; and ¶Centre National de la
Recherche Scientifique, Unite Mixte de Recherche 177, Institut Curie, 91405 Orsay, France
Contributed by Richard F. Thompson, March 31, 1997
ABSTRACT Mice deficient in monoamine oxidase A
(MAOA), an enzyme that metabolizes monoamines such as
norepinephrine and serotonin, have elevated norepinephrine
and serotonin levels in the frontal cortex, hippocampus, and
cerebellum, compared with normal wild-type mice. Since
monoamines in these areas are critically involved in a variety
of behaviors, we examined learning and memory (using emo-

  

Source: Anagnostaras, Stephan - Neurosciences Program & Department of Psychology, University of California at San Diego

 

Collections: Biology and Medicine