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Title of Document: A SYSTEMS ENGINEERING FRAMEWORK FOR METABOLIC
 

Summary: ABSTRACT
Title of Document: A SYSTEMS ENGINEERING
FRAMEWORK FOR METABOLIC
ENGINEERING EXPERIMENTS
Joseph Johnnie, Master of Science in Systems
Engineering, 2011
Directed By: Dr. Mark Austin, Department of Civil and
Environmental Engineering, and the Institute
for Systems Research, University of Maryland
at College Park
Cells of living organisms simultaneously operate hundreds or thousands of
interconnected chemical reactions. Metabolic networks include these chemical reactions
and compounds participating in them. Metabolic engineering is a science centered on the
analysis and purposeful modification of an organism's metabolic network toward a
beneficial purpose, such as production of fuel or medicinal compounds in
microorganisms. Unfortunately, there are problems with the design and visualization of
modified metabolic networks due to lack of standardized and fully developed visual
modeling languages. The purposes of this paper are to propose a multilevel framework
for the synthesis, analysis and design of metabolic systems, and then explore the extent to
which abstractions from systems engineering (e.g., SysML) can complement and add

  

Source: Austin, Mark - Institute for Systems Research & Department of Civil and Environmental Engineering, University of Maryland at College Park

 

Collections: Engineering