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Behavioral/Systems/Cognitive Relationship between Complex and Simple Spike Activity
 

Summary: Behavioral/Systems/Cognitive
Relationship between Complex and Simple Spike Activity
in Macaque Caudal Vermis during Three-Dimensional
Vestibular Stimulation
Tatyana Yakusheva,1 Pablo M. Blazquez,2 and Dora E. Angelaki1
Departments of 1Neurobiology and 2Otolaryngology, Washington University School of Medicine, St. Louis, Missouri 63110
Lobules10and9inthecaudalposteriorvermis[alsoknownasnodulusanduvula(NU)]arethoughtimportantforspatialorientationand
balance.Here,wecharacterizecomplexspike(CS)andsimplespike(SS)activityinresponsetothree-dimensionalvestibularstimulation.
Thestrongestmodulationwasseenduringtranslation(CS:12.8 1.5,SS:287.0 23.2spikes/s/G,0.5Hz).Preferreddirectionstendedto
clusteralongthecardinalaxes(lateral,fore-aft,vertical)forCSsandalongthesemicircularcanalaxesforSSs.Mostnotably,thepreferred
directions for CS/SS pairs arising from the same Purkinje cells were rarely aligned. During 0.5 Hz pitch/roll tilt, only about a third of CSs
had significant modulation. Thus, most CSs correlated best with inertial rather than net linear acceleration. By comparison, all SSs were
selective for translation and ignored changes in spatial orientation relative to gravity. Like SSs, tilt modulation of CSs increased at lower
frequencies.CSsandSSshadsimilarresponsedynamics,respondingtolinearvelocityduringtranslationandangularpositionduringtilt.
The most salient finding is that CSs did not always modulate out-of-phase with SSs. The CS/SS phase difference varied broadly among
Purkinje cells, yet for each cell it was precisely matched for the otolith-driven and canal-driven components of the response. These
findings illustrate a spatiotemporal mismatch between CS/SS pairs and provide the first comprehensive description of the macaque NU,
an important step toward understanding how CSs and SSs interact during complex movements and spatial disorientation.
Introduction
The vestibulo-cerebellum (flocculus, ventral paraflocculus, nod-

  

Source: Angelaki, Dora - Department of Anatomy and Neurobiology, Washington University in St. Louis

 

Collections: Biology and Medicine